Structure Elucidation of Pandangolide 1 Isolated From Lambertella Brunneola
نویسنده
چکیده
A macrolide compound known as pandangolide 1 was isolated from fungus Lambertella brunneola. The compound was purified using SiO2 column chromatography while the elucidation of its planar structure was based on the analyses of Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS). Antifungal assay disclosed that pandangolide 1 weakly showed hyphal growth inhibition against pathogenic fungus Cochliobolus miyabeanus at 2,000 g/mL. This is the first paper to report the isolation of Pandangolide 1 from L. brunneola.
منابع مشابه
Pandangolide 1a, a metabolite of the sponge-associated fungus Cladosporiumsp., and the absolute stereochemistry of pandangolide 1 and iso-cladospolide B.
Fractionation of the ethyl acetate extract of a Cladosporium sp., isolated from the Red Sea sponge Niphates rowi, yielded a new hexaketide, pandangolide 1a (1), together with its known diastereomer pandangolide 1 (2) and the known iso-cladospolide B (3). The structures of the compounds were determined by 1D and 2D NMR techniques and mass spectrometric data. The absolute configurations of the st...
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